NASA GeneLab Multi-Omics Data on Spaceflight Impact

NASA's GeneLab data and astronaut biomedical profiles provide a multi-omics, systems biology analysis of spaceflight impact. The data consist of hundreds of samples flown in space, human metrics from 59 astronauts, and confirmatory data from NASA's Twin Study. It was analyzed for consistent transcriptomic, proteomic, metabolomic, and epigenetic responses, revealing mitochondrial stress as a central phenotype.

Use Cases

• Identify biomarkers of spaceflight stress based on multi-omics profiles from astronaut cohorts.
• Model interactions between mitochondrial dysfunction and chronic inflammation using pathway analysis results.
• Investigate the impact of spaceflight on circadian rhythm and olfactory pathways linked to mitochondrial activity.
• Validate findings from the NASA Twin Study using the broader dataset of hundreds of flown samples.

Strengths

• Integrates data from hundreds of samples flown in space.
• Includes human metrics from a cohort of 59 astronauts.
• Combines multiple omics layers: transcriptomic, proteomic, metabolomic, and epigenetic.
• Incorporates confirmatory data from NASA's Twin Study.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• Data is provided in a BIN format, which may require specialized tools for access.

Provenance

Source

National Aeronautics and Space Administration (NASA)

Collection Method

Multi-omics, systems biology analysis of NASA GeneLab data and astronaut biomedical profiles.

Freshness

Last updated 2026-03-13 19:43:44.393993; freshness should be verified.