Radiation Necrosis Risk Factors in Lung Cancer Brain Metastases

136 patients with brain metastases from lung cancer were analyzed in a retrospective single-center cohort study. The dataset supports analysis of risk factors for radiation necrosis and local control after stereotactic radiosurgery, with findings indicating a 16.2% incidence of necrosis. It includes variables for treatments like immunotherapy and whole-brain radiation therapy, as well as dosimetric and volumetric data.

Use Cases

• Risk factor modeling for radiation necrosis based on treatment history and tumor volume
• Survival analysis (e.g., local control, radiation necrosis-free survival) using Kaplan-Meier and Cox regression methods
• Evaluating the association between biologic effective dose (BED10) and local tumor control
• Studying the interaction between stereotactic radiosurgery and concurrent immunotherapy or tyrosine kinase inhibitors

Strengths

• Includes specific clinical outcome metrics: 22 out of 136 patients (16.2%) developed radiation necrosis, with a median time to development of 11.73 months
• Dataset is derived from a formal clinical study with defined primary (radiation necrosis) and secondary (local control) endpoints
• Available under a permissive CC-BY-4.0 license, facilitating reuse and sharing

Limitations

• Column names and a complete data dictionary are not provided, limiting understanding of the specific variables available
• The dataset appears to be a static analysis supporting a single publication, with no indication of ongoing updates
• Row count is inconsistently reported as 'unknown' and 'None' across platform entries

Provenance

Source

Retrospective single-center cohort study authored by Guochang Du

Collection Method

Clinical data collection from patients treated with stereotactic radiosurgery for brain metastases

Freshness

Last updated 2026-03-20