Copper-Photocatalyzed Enantioselective S-Alkylation Data

A 337.5 KB dataset from figshare details a method for creating chiral sulfilimines, important motifs in medicinal chemistry. The work by Xiangyu Zhuang, last updated in March 2026, describes a copper-photoredox catalysis strategy using amino-acid-derived ligands. This method tolerates a broad range of primary, secondary, and tertiary alkyl radicals and diverse sulfenamides.

Use Cases

• Training ML models for reaction outcome prediction based on described substrate scope and ligand families.
• Benchmarking computational chemistry methods against experimental results for enantioselective S-alkylation.
• Informing ligand design for copper-photoredox catalysis based on the performance of the reported N,N,N-tridentate ligands.

Strengths

• Data is associated with a specific, peer-reviewed synthetic methodology published on an academic platform.
• The description details a broad substrate scope, including primary, secondary, and tertiary alkyl radicals and complex bioactive substrates.

Limitations

• Row count is unknown, which may limit suitability assessment.
• Column-level documentation is absent; field semantics must be inferred after download.
• The dataset is small at 337.5 KB, indicating limited scope.

Provenance

Source

figshare, authored by Xiangyu Zhuang.

Collection Method

Likely contains experimental data supporting the described chemical synthesis methodology.

Freshness

Last updated 2026-03-26 02:29:38; freshness should be verified.