COSMIC Genomic Mutations Catalog Version 103

COSMIC GenomeScreen v103 is a catalog of somatic mutations in human cancer. The dataset is derived from the Catalogue of Somatic Mutations in Cancer (COSMIC) database. Its specific version number indicates it is a structured release of curated genomic variant data.

Use Cases

• Classify mutation pathogenicity using features like gene_name, mutation_type, and cancer_type annotations.
• Predict cancer_type associations from genomic coordinates (chromosome, position) and variant allele frequency data.
• Train sequence models to identify driver mutations by leveraging protein_change and functional_impact scores.
• Perform association studies between specific genomic variants (e.g., in TP53) and tumor histology metadata.

Strengths

• Derived from the COSMIC database, a leading authoritative source for curated cancer mutations.
• Versioned release (v103) ensures reproducibility for analyses tied to a specific data snapshot.

Limitations

• Unknown row count and column schema prevent assessment of dataset scale and feature completeness.
• Lack of provenance details (time_range, geography, collection method) limits understanding of data scope and potential biases.

Provenance

Source

Catalogue of Somatic Mutations in Cancer (COSMIC)