BisPA Compound Data for Phosphatidylglycerol Binding and Antimicrobial Activity

2026 data from Xubo Tong details the design and testing of BisPA miniature peptidomimetics targeting phosphatidylglycerol. The dataset includes molecular binding affinities, such as a Kd of 1.4 × 10–6 M for BisPA14, and results from in vitro and in vivo infection models. It supports research into resistance-suppressing antimicrobial agents.

Use Cases

• Analyze the relationship between molecular structure and PG-binding affinity (Kd) for BisPA compounds.
• Compare the therapeutic efficacy of BisPA14 across intraperitoneal, pulmonary, and bloodstream infection models.
• Investigate the dual-targeting mechanism data linking membrane disruption and bacterial DNA engagement.
• Model the suppression of resistance evolution using data from persister bacterial population studies.

Strengths

• Includes precise quantitative binding affinity measurements, such as Kd(BisPA14) = 1.4 × 10–6 M.
• Contains experimental results from multiple in vivo infection models (intraperitoneal, pulmonary, bloodstream).
• Data is recent, last updated in March 2026.

Limitations

• The dataset is small at 152.3 KB, indicating limited scope and likely a focused experimental dataset.
• Specific row and column counts, sample data, and data structure are unknown from the input.
• The dataset appears focused on a specific class of compounds (BisPAs), limiting generalizability.

Provenance

Source

Xubo Tong via figshare.

Collection Method

Experimental data from the rational design and testing of BisPA compounds.

Freshness

Last updated 2026-03-23.