Cross-Species Placental Evolution Single-Cell Atlas of 300,000 Cells

Approximately 300,000 single-cell transcriptomic profiles from ten mammalian species, representing four primary placental types, were generated by author Guanghui Tan and shared on figshare. The dataset, last updated in May 2026, provides a framework for analyzing the molecular evolution of the placenta and its link to pregnancy diseases. It includes data on key regulators like TGIF1 and associated genes ADAM12, WNT3A, and ZNF831.

Use Cases

• Identify cross-species trophoblast lineage differentiation trajectories based on single-cell transcriptomic data.
• Analyze regulatory networks shaping trophoblast development across diverse placental architectures.
• Investigate gene expression profiles associated with human pregnancy complications like preeclampsia and miscarriage.
• Validate the role of specific regulators like TGIF1 and its targets (ADAM12, WNT3A, ZNF831) in trophoblast function.

Strengths

• Dataset comprises a substantial volume of ~300,000 single cells.
• Cross-species design includes ten species covering four primary placental types (discoid, cotyledonary, diffuse, zonary).
• Includes functional experimental insights linking TGIF1 to trophoblast growth and migration.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment for specific analytical needs.

Provenance

Source

figshare, author Guanghui Tan

Collection Method

Single-cell transcriptomic sequencing of placental samples from ten species.

Freshness

Last updated 2026-05-13 09:03:29