Review of Vimentin and Keratin Roles in Viral Infection Life Cycle

A 2026 narrative review by Xiaolong Lu synthesizes recent studies on intermediate filaments in virology. The document analyzes how vimentin and keratins influence viral attachment, replication, trafficking, assembly, and egress. It further discusses their roles in cell-to-cell spread, immune regulation, and oncogenic processes.

Use Cases

• Extract structured information on vimentin's role in viral entry and replication stages for knowledge graph construction.
• Analyze the text for mentions of keratin interactions during viral assembly and egress to identify research themes.
• Use the review's discussion on host immune regulation to train an NLP model for classifying virology literature.

Strengths

• Authored by a subject-matter expert and published in 2026, ensuring contemporary scientific perspective.
• Released under a permissive CC BY 4.0 license, allowing for broad reuse and redistribution.
• Covers multiple specific viral life cycle stages including attachment, replication, and egress.

Limitations

• The 89.4 KB file is a narrative review document, not a structured dataset, limiting quantitative analysis.
• Contains no primary data, rows, or columns, relying solely on synthesis of existing literature.
• Scope is limited to the specific biological focus on vimentin and keratins, not all intermediate filaments.

Provenance

Source

figshare, authored by Xiaolong Lu.

Collection Method

Narrative literature review.

Time Range

Covers studies up to the publication date circa 2026.

Freshness

Last updated March 2026.