PvdL Cross-Module Constructs: Cryo-EM Density Maps

Wei Cao's dataset provides Cryo-EM density maps for three PvdL cross-module constructs: PvdL-E2-C3-A3-PCP3, PvdL-PCP2-E2-C3-A3-core, and PvdL-E2-C3-A3-core-R3393A. These maps were used to elucidate the tetrahydropyrimidine cyclization mechanism and stereochemical control by the PvdL-C3 domain. The dataset supports research published in Nature Synthesis and the final maps and models are deposited in the EMDB and PDB.

Use Cases

• Analyzing the 3D structure of PvdL condensation domains based on the provided MRC map files.
• Studying the mechanism of tetrahydropyrimidine cyclization based on the described research context.
• Validating or comparing atomic models (PDB 9UP2, 9LCO, 9LCP, 9LCQ) against the experimental density maps.
• Investigating stereochemical control in enzymatic synthesis based on the role of the PvdL-C3 domain.

Strengths

• Includes data from a study published in the high-impact journal Nature Synthesis.
• Provides direct links to public repositories with specific accession codes (EMDB-64387, EMD-62988, etc.).
• Dataset is large, with a reported size of approximately 2.43 GB, suggesting detailed map information.

Limitations

• Column names and row counts are not provided, limiting understanding of the dataset's internal structure.
• The dataset consists solely of processed output maps and models; raw imaging data is not included.
• The 'Finance' tag from one platform entry appears to be a clear mis-tagging error.

Provenance

Source

Research by Wei Cao, associated with a Nature Synthesis publication.

Collection Method

Data generated via Cryo-Electron Microscopy and subsequent processing; final maps deposited in EMDB and PDB.

Time Range

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Freshness

Last updated on 2026-03-24.

Geography

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