Cryo-EM Structure of the Ca2+-Bound hsSlo1-beta4 Channel Complex

A structural biology dataset from the Howard Hughes Medical Institute, authored by X. Tao. The data likely describes the cryo-electron microscopy structure of the hsSlo1-beta4 ion channel complex. The description suggests the dataset includes information on how the beta4 subunit modulates channel gating and scorpion toxin inhibition.

Use Cases

• Modeling ion channel gating mechanisms based on described conformational states.
• Studying protein subunit modulation based on the role of the beta4 subunit.
• Analyzing toxin inhibition kinetics based on the described 'crown' structure that constrains access.

Strengths

• Data originates from the Howard Hughes Medical Institute, a leading research organization.
• The description provides specific biological insights into channel gating and toxin inhibition.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• Last update date is unknown; freshness unverified.

Provenance

Source

Howard Hughes Medical Institute

Collection Method

Cryo-electron microscopy, as indicated by the title.