Mouse TRPV3 Ion Channel Cryo-EM Structures in Closed and Open States

Cryo-electron microscopy structures of the full-length mouse TRPV3 ion channel, presented by a researcher from Columbia University. The dataset includes the channel in both a closed apo state and an agonist-bound open state, revealing conformational changes in the pore and gate. These findings are intended to aid in understanding TRP channel activation and designing drugs for skin conditions, itch, and pain.

Use Cases

• Modeling ion channel gating mechanisms based on described conformational changes in the S6 helices.
• Studying allosteric agonist binding based on the three distal binding sites mentioned.
• Aiding structure-based drug design for inflammatory skin conditions based on the open-state structure.
• Comparing TRP channel family activation based on the described α-to-π helical transitions.

Strengths

• Structures capture both closed and agonist-bound open states, enabling comparative analysis.
• Findings are linked to specific physiological roles and diseases like Olmsted syndrome and atopic dermatitis.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• Last update date is unknown; freshness unverified.

Provenance

Source

paperswithcode

Collection Method

Cryo-electron microscopy