Cryo-EM structure of the circumsporozoite protein of Plasmodium falciparum with a vaccine-

A cryo-electron microscopy structure at approximately 3.4-Å resolution reveals the conformation of a recombinant Plasmodium falciparum circumsporozoite protein bound to a protective monoclonal antibody. The data, from the Scripps Research Institute, shows an extended spiral structure of the central NANP repeat region surrounded by antibodies. The structure suggests somatic mutations in antibody contacts may enhance targeting of tandem repeat sequences.

Use Cases

• Modeling antibody-antigen interactions based on the described cryo-EM structure.
• Studying protein conformation and disorder in the NANP repeat region of CSP.
• Investigating antibody maturation mechanisms for targeting tandem repeat sequences.
• Informing rational vaccine design against Plasmodium falciparum based on structural insights.

Strengths

• Cryo-EM structure resolved at approximately 3.4-Å resolution.
• Data reveals specific structural details of an antibody-protein complex relevant to malaria.

Limitations

• Row count and dataset scale are unknown, which may limit suitability assessment.
• Column-level documentation is absent; field semantics must be inferred after download.
• Last update date is unknown; freshness unverified.

Provenance

Source

Scripps Research Institute

Collection Method

Cryo-electron microscopy