CryoEM Structures of Human Enterovirus D68 Full Virion and Uncoating Intermediates

Cryoelectron microscopy structures of the full native virion and an uncoating intermediate of Enterovirus D68, determined at 2.2- and 2.7-Å resolution, respectively. The data, produced by researchers at Purdue University West Lafayette, delineates the pathway of EV-D68 uncoating and provides the molecular basis for its acid lability.

Use Cases

• Modeling virus capsid dynamics based on described particle expansion and pore formation.
• Studying acid-induced structural transitions in viruses based on the described pH treatment experiments.
• Comparing ordered internal regions of viral proteins across different structural intermediates like the E1 particle.

Strengths

• High-resolution structures determined at 2.2- and 2.7-Å resolution.
• Captures multiple structural intermediates during the virus uncoating process.
• Describes a previously undescribed structural state, the expanded 1 (E1) particle.

Limitations

• Row count is unknown, which may limit suitability assessment.
• Column-level documentation is absent; field semantics must be inferred after download.
• Last update date is unknown; freshness unverified.

Provenance

Source

Purdue University West Lafayette

Collection Method

Cryoelectron microscopy (cryo-EM)