Cardiac Electrophysiology in Cystic Fibrosis Animal Models

Research data investigates the role of the CFTR gene in cardiomyocytes and its link to cardiac arrhythmias. The dataset includes electrocardiogram (EKG) recordings from CFTR-/- piglets under epinephrine stress and tissue analysis from mouse and induced pluripotent stem cell models. The study was authored by Dai, Dao-Fu and was last updated in April 2026.

Use Cases

• Analyze EKG waveform features from CFTR-/- piglets to predict susceptibility to QT prolongation and ventricular tachycardia.
• Model the relationship between CFTR mutation status (e.g., F508d) and mitochondrial signaling metrics in cardiomyocyte data.
• Train classifiers to differentiate cardiac tissue analysis results from MHC-CFTR-/- mice, F508d mutant mice, and iPS-CM models.
• Correlate the application of CFTR correctors with changes in hERG channel modulation parameters described in the study aims.

Strengths

• Data is derived from multiple controlled experimental models including genetically modified pigs, mice, and iPS cells.
• Study design includes specific, hypothesis-driven aims focusing on mechanistic pathways.

Limitations

• The exact sample size (number of animals, cells, or records) is not provided, limiting assessment of statistical power.
• Specific data columns, file formats, and the total volume of data are unknown.

Provenance

Source

Harvard Dataverse, authored by Dai, Dao-Fu.

Collection Method

Experimental data from animal models (piglets, mice) and induced pluripotent stem cell-derived cardiomyocytes, including EKG recordings and tissue analysis.

Freshness

Last updated in April 2026, indicating recent maintenance.