Cytokines and Inflammatory Gene Polymorphisms Associated with Nosocomial Pulmonary Infecti

118.6 KB of clinical data from a retrospective cohort analysis of patients with spontaneous intracereerebral hemorrhage (ICH). The dataset, authored by Lunyun Yang and last updated in April 2026, compares patients who developed nosocomial pulmonary infection with those who did not. It includes measurements of serum cytokines (IL-1β, IL-6, IL-10, IL-17, IFN-γ, TNF-α), TLR protein levels, and immune-related gene polymorphisms.

Use Cases

• Identify genetic risk factors for hospital-acquired pneumonia based on polymorphisms in IL-1B, IL-10, TNF-α, TLR2, and TLR9 genes mentioned in the description.
• Analyze associations between serum cytokine profiles (IL-1β, IL-6, IL-10, IL-17, IFN-γ, TNF-α) and infection susceptibility after brain hemorrhage.
• Build predictive models for nosocomial infection risk using combined biomarker data from cytokine levels and host genetic markers.
• Validate inflammatory pathways implicated in secondary complications following spontaneous intracerebral hemorrhage.

Strengths

• Dataset is 118.6 KB in size and available in XLSX format for direct analysis.
• License is CC-BY-4.0, permitting broad reuse with attribution.
• Description specifies concrete biomarkers measured, including six cytokines and three TLR protein levels.
• Analysis is based on a defined clinical cohort comparing infected and non-infected patient groups.

Limitations

• Row count is unknown, which may limit suitability assessment for large-scale modeling.
• Column-level documentation is absent; field semantics must be inferred after download.
• The description notes prospective multicenter validation is still required before clinical implementation.

Provenance

Source

figshare, author Lunyun Yang.

Collection Method

Retrospective cohort analysis of patients with primary spontaneous intracerebral hemorrhage.

Freshness

Last updated 2026-04-26 12:53:44; freshness should be verified.