CRES Knockout Mouse Data on Brain ECM Structure and Sex-Specific Learning/Memory

Tabular data from a study investigating the role of the functional amyloid Cystatin-related epididymal spermatogenic (CRES) protein in brain extracellular matrix (ECM) structure and behavior. The dataset, authored by Alejandra Gomez and shared on figshare, compares CRES knockout (KO) and wild-type (WT) mice, analyzing sex-specific changes in hippocampal and cortical ECM and behavioral deficits. It was last updated on 2026-05-27.

Use Cases

• Analyze sex-specific structural changes in brain extracellular matrix (ECM) based on the description of loose/interstitial and perineuronal net (PNN) ECM.
• Investigate correlations between ECM structure and behavioral deficits based on the described learning, memory, and executive functioning tests in mice.
• Study the age-related plasticity of the brain ECM based on the observation that behavioral deficits in young males were not present in older males.
• Compare genotype (CRES KO vs. WT) effects on brain structure and function as described in the study.

Strengths

• Data is associated with a peer-reviewed manuscript, providing a research context.
• Dataset includes sex-specific and age-specific comparisons (young vs. older mice) as described.
• Available under a permissive CC-BY-4.0 license for reuse.

Limitations

• Row count is unknown, which may limit suitability assessment.
• Column-level documentation is absent; field semantics must be inferred after download.
• The 1.0 MB file size suggests a relatively small dataset.

Provenance

Source

figshare, authored by Alejandra Gomez.

Collection Method

Likely contains experimental measurements from a CRES knockout mouse model study.

Freshness

Last updated 2026-05-27 15:50:42; freshness should be verified.