Persistent Synaptic Alterations in Dravet Syndrome Mouse Thalamus

Mona Safari's dataset contains electrophysiological data associated with the study 'Persistent input- and cell-type-specific synaptic alterations in the somatosensory thalamus of Dravet syndrome mice'. The data, last updated on 2026-05-20, is stored in ZIP and RTF formats and totals 8.5 MB. It investigates synapse function in the ventral posterolateral (VPL) and ventral posteromedial (VPM) thalamus of mice at three developmental stages.

Use Cases

• Analyze excitatory and inhibitory synaptic input changes based on developmental stage (P13-P17, P28-P32, P58-P63) mentioned in the description
• Compare synapse dysfunction between VPL and VPM thalamic nuclei based on the described cell-type-specific alterations
• Investigate the persistence of synaptic deficits into adulthood based on the described long-term circuit dysfunction
• Study the relationship between seizure onset and subsequent synaptic alterations based on the described disease progression

Strengths

• Data covers three distinct developmental time points (pre-seizure onset, post-high seizure burden, adulthood) as described.
• Focuses on two specific thalamic nuclei (VPL and VPM) allowing for cell-type-specific analysis.
• Released under a permissive CC0-1.0 license for broad reuse.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• The 8.5 MB size suggests a relatively small-scale dataset.

Provenance

Source

figshare, author Mona Safari

Collection Method

Likely contains experimental electrophysiological recordings from mouse brain slices.

Time Range

Data collected from mice aged postnatal days 13-17, 28-32, and 58-63.

Freshness

Last updated 2026-05-20 20:29:37