TDP-43CTD Droplet and Fibril Microscopy Images with Time-Series Data

Data associated with 'Site-specific Raman Probes Reveal Droplet Aging and Residue-level Fibril Polymorphism in TDP-43CTD' by Matthew Watson, published on figshare in 2026. The dataset contains 116.5 MB of microscopy images (TIF) and likely tabular data (XLSX) tracking protein droplet formation and fibril polymorphism over time.

Use Cases

• Train image segmentation models to identify protein droplets and fibrils based on bright field and fluorescence images.
• Analyze the kinetics of droplet aging and fibril formation based on time-series images captured at 1, 24, 48, and 95 hours.
• Study the effect of specific amino acid mutations (e.g., F283F, W334F, Y374F) on fibril polymorphism using images of different protein variants.

Strengths

• Includes time-series images capturing droplet and fibril morphology at specific time points (e.g., 1h, 48h, 95h).
• Contains images of multiple protein variants and polymorphs, enabling comparative analysis of fibril structure.
• Dataset size is 116.5 MB, providing a medium-scale collection of raw image data.

Limitations

• Column-level documentation is absent; field semantics in the XLSX files must be inferred after download.
• Row count is unknown, which may limit suitability assessment for statistical modeling.
• Description metadata is limited; actual data quality and annotation require manual inspection after download.

Provenance

Source

Matthew Watson via figshare.

Collection Method

Likely generated from laboratory microscopy experiments as part of the cited research.

Time Range

Time points referenced include 1, 24, 25, 26, 48, and 95 hours after droplet formation.

Freshness

Last updated 2026-06-02 17:16:21; freshness should be verified.