96 Schistosoma Mansoni Antigen Screening Data from Mouse Vaccine Trials

Cécile Crosnier produced data from a systematic screening of 96 Schistosoma mansoni cell-surface and secreted antigens for vaccine potential. The data record consists of nine datasets covering protocol optimization, antibody titres, and parasite burden correlations. The datasets were generated using standardized immunization and percutaneous infection protocols in BALB/C female mice.

Use Cases

• Optimizing percutaneous challenge protocols based on duration and rest period data
• Evaluating vaccine candidate efficacy based on half-maximal antibody titre measurements
• Analyzing correlations between parasite egg counts and adult worm or mature female counts
• Validating antigen production and integrity using SDS-page gel data
• Comparing individual and cohort-level responses for specific antigens like Protein 10 and 58

Strengths

• Systematic comparison of 96 recombinant antigens under standardized protocols
• Includes data from multiple experimental phases: optimization, antibody response, and parasite burden
• Data is provided in both specialized (.pzf) and accessible (.xlsx, .pptx) file formats

Limitations

• Column-level documentation is absent; field semantics must be inferred after download
• Row count is unknown, which may limit suitability assessment
• Last update date is unknown; freshness unverified

Provenance

Source

Cécile Crosnier

Collection Method

Generated from mouse immunization and infection experiments using a mammalian expression system for antigen production.