ERK Signaling in Nascent Adhesion Dynamics for Cell Migration

Mendoza's research dataset from 2026 investigates how the ERK signaling pathway regulates nascent adhesions to drive persistent cell edge protrusion and migration. The dataset, 4.8 GB in size, includes data from experiments using an ERK FRET biosensor targeted to adhesions. It was published on figshare under a CC0-1.0 license.

Use Cases

• Quantify ERK activity dynamics in assembling and disassembling nascent adhesions based on FRET biosensor data
• Model the relationship between ERK activation levels and adhesion turnover rates described in the study
• Analyze the correlation between short-lived nascent adhesion populations and edge protrusion persistence
• Validate computational models of the RAS-RAF-MEK-ERK pathway's role in adhesion regulation

Strengths

• Dataset size is 4.8 GB, indicating substantial raw or processed data.
• Published in a peer-reviewed PNAS article from 2026, suggesting scientific rigor.
• Released under a permissive CC0-1.0 license for unrestricted reuse.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• Data may reflect experimental bias inherent to the specific cell lines and conditions used.

Provenance

Source

Author Mendoza, platform figshare.

Collection Method

Likely contains experimental microscopy and biosensor data from cell migration studies.

Freshness

Last updated 2026-05-27 19:03:15; freshness should be verified.