GAW18: Human Whole Genome Sequence and Blood Pressure Data in Mexican American Pedigrees

Mexican American families provided data for Genetic Analysis Workshop 18, focusing on genes influencing complex traits. The dataset includes whole genome sequences for 464 key individuals from 20 families, SNP data for 959 individuals, and longitudinal blood pressure measurements over 20 years. Simulated phenotypes based on the real data, with 200 replicates for 849 individuals each, were created by Laura Almasy of the Texas Biomedical Research Institute.

Use Cases

• Identify genetic variants associated with blood pressure based on whole genome sequence data from extended pedigrees.
• Develop methods for longitudinal phenotype analysis using blood pressure measurements taken at 1-4 examinations over 20 years.
• Benchmark simulation models for complex traits using the provided 200 replicates of simulated phenotypes.
• Study genotype-medication interactions using simulated phenotypes modeled with such effects.

Strengths

• Includes real whole genome sequence data for odd-numbered autosomes in 464 individuals from 20 Mexican American families.
• Contains longitudinal systolic and diastolic blood pressure data collected over a period of 20 years.
• Provides 200 simulation replicates with phenotypes modeled on real trait distributions, including age, sex, and medication effects.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count for the primary sequence and phenotype tables is unknown, which may limit suitability assessment.
• Last update date is unknown; freshness unverified.

Provenance

Source

T2D-GENES Consortium, donated for Genetic Analysis Workshop 18.

Collection Method

Whole genome sequencing, SNP genotyping, and longitudinal clinical measurement.

Time Range

Blood pressure data collected over a 20-year period.

Geography

Data from Mexican American families.