T Cell-Derived IL-17A in Periodontitis Under Insulin Resistance

A 4948-participant NHANES analysis links insulin resistance to periodontitis risk (Odds Ratio=1.22). This dataset supports a murine model study investigating IL-17A's role in immune cell infiltration and bone loss, published by Chengzhe Wang in 2026. It includes bulk RNA sequencing, flow cytometry, and micro-CT data.

Use Cases

• Validate the clinical association between insulin resistance and periodontitis based on NHANES participant data.
• Analyze immune cell infiltration patterns in gingival tissue based on flow cytometry and immunofluorescence data.
• Model alveolar bone loss under insulin resistance based on micro-computed tomography measurements.
• Investigate gene expression changes in inflammatory pathways based on bulk RNA sequencing results.
• Study the effects of IL-17A on fibroblast function and collagen metabolism based on in vitro experiments.

Strengths

• Includes data from a large-scale human study of 4948 participants from NHANES 2009–2014.
• Combines clinical, murine model, and in vitro cell data for a multi-faceted investigation.
• Employs multiple experimental techniques: bulk RNA sequencing, flow cytometry, micro-CT, and histological staining.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment for large-scale ML tasks.
• Data may reflect geographic and temporal bias inherent to the NHANES and experimental model sources.

Provenance

Source

figshare, author Chengzhe Wang

Collection Method

Clinical analysis of NHANES data combined with experimental murine model and in vitro cell studies.

Time Range

Human data from NHANES 2009–2014; experimental data collection date unspecified.

Freshness

Last updated 2026-05-23 12:45:31

Geography

United States (NHANES); experimental model location unspecified.