Cytoplasmic Dynein Stepping Model Data from Mathematical Framework

A mathematical model describes the stepping behavior of cytoplasmic dynein 1, a dimeric motor protein, on microtubules. The framework examines experimental observations across species and predicts temporal dynamics of subunits like AAA+ rings and microtubule binding domains. It includes model extensions for backward stepping, variable step size, and dwelling.

Use Cases

• Validate the model's prediction of weakly coordinated stepping patterns and not passing steps against experimental dynein observations.
• Use the mathematical framework to simulate temporal dynamics of individual dynein components, such as cargo and AAA+ rings, not yet experimentally measured.
• Analyze the model's extension for backward stepping and variable step size to understand dynein's adaptability in intracellular transport.
• Apply the model to investigate the importance of interhead coordination in the ATP cycle for achieving alternating stepping patterns and long run lengths.

Strengths

• Model is based on the physical principles and whole structure of cytoplasmic dynein 1, including key subunits.
• Framework is designed to examine experimental observations across a wide range of different species.
• Model extensions include backward stepping, variable step size, and dwelling, increasing its scope.

Limitations

• Dataset specifics like row count, column names, and sample data are unavailable, limiting direct analytical use.
• The data is derived from a theoretical model; validation requires external experimental datasets.
• Last updated in June 2020, so it may not reflect the most recent experimental findings.

Provenance

Source

Dryad

Collection Method

Mathematical modeling based on physical principles of cytoplasmic dynein 1 structure and behavior.

Freshness

Last updated 2020-06-30.