Pneumococcal Carriage in Western Australian Children from 1999 to 2005

From 1999 to 2005, a longitudinal study followed 280 Aboriginal and non-Aboriginal children from birth to two years, collecting nasopharyngeal aspirates at seven time points. The data characterizes pneumococcal serotypes, genotypes, and antimicrobial susceptibility profiles, enabling evaluation of the 7-valent pneumococcal conjugate vaccine's impact on carriage.

Use Cases

• Analyze pneumococcal serotype prevalence and distribution between Aboriginal and non-Aboriginal child cohorts.
• Investigate the association between 7vPCV vaccine doses received and the odds of carrying vaccine versus non-vaccine serotypes.
• Study antimicrobial susceptibility patterns and the presence of multi-resistant clones like ST90.
• Examine molecular epidemiology data from pulse-field gel electrophoresis and multilocus sequence typing of isolates.

Strengths

• Longitudinal design with data collection at seven specific time points from birth to 24 months.
• Comparative analysis of 280 children from two distinct demographic groups (100 Aboriginal, 180 non-Aboriginal).
• Includes detailed laboratory data on serotyping, antimicrobial susceptibility, and molecular genotyping.

Limitations

• Sample size is limited to 280 children from a specific region of Western Australia.
• Data collection ended in 2005, preceding the widespread use of newer pneumococcal vaccines.
• No column-level metadata or sample data is provided to assess the dataset's structure.

Provenance

Source

Eileen M. Dunne, via the Kalgoorlie Otitis Media Research Project.

Collection Method

Nasopharyngeal aspirates collected from children; pneumococci characterized by Quellung serotyping, disk diffusion/Etest® for antimicrobial susceptibility, and molecular typing.

Time Range

1999 to 2005.

Freshness

Last updated in 2020, but primary data covers 1999-2005.

Geography

Western Australia, specifically the Kalgoorlie region.