Parkinson Disease Brain Connectivity Changes After AMPS Stimulation

Aggregating fMRI data from a double-blind sham-controlled pilot trial with 11 patients (6 women, 5 men) with idiopathic Parkinson Disease. It captures resting-state functional connectivity (RSFC) before and after effective or sham Automatic Mechanical Peripheral Stimulation (AMPS), focusing on seed ROIs in basal ganglia, sensory-motor cortices, supplementary motor areas, and cerebellum.

Use Cases

• Compare pre- and post-effective AMPS RSFC changes in the sensory motor cortex seed ROI to identify stimulus-specific neural modulation.
• Analyze individual differences in striatum nucleus connectivity with the right lateral occipital cortex (max Z score 3.12) to assess treatment response variability.
• Evaluate cerebellum seed ROI connectivity changes with the right cerebellar cortex (max Z score 3.79) post-stimulation for visuo-spatial integration effects.
• Contrast RSFC outcomes between effective AMPS and sham conditions using paired group t-test analysis frameworks.

Strengths

• Data originates from a controlled, double-blind sham-controlled pilot trial (ClinicalTrials.gov NCT01815281), providing a structured experimental design.
• Includes fMRI scans from 11 patients with idiopathic Parkinson Disease, offering a specific clinical cohort.
• RSFC analysis uses specific seed ROIs in key brain regions like basal ganglia and cerebellum, enabling targeted connectivity studies.

Limitations

• Small sample size of 11 patients limits statistical power and generalizability of findings.
• As a pilot study, the data may require validation in larger, independent cohorts.
• Temporal coverage is limited to acute pre- and post-stimulation measurements, lacking long-term follow-up data.

Provenance

Source

Dryad, authored by Carlo Cosimo Quattrocchi.

Collection Method

Collected via brain fMRI immediately before and after sham or effective AMPS in a clinical trial setting; RSFC assessed using seed-ROI based analysis.

Time Range

Timing of the pilot trial is not specified, but data reflects acute pre- and post-stimulation time points.

Freshness

Data was last updated on 2020-06-24.