Drosophila Allatostatin A Signaling Data on Feeding and Sleep

Experimental data from a 2020 study investigates the role of Allatostatin A (AstA) signaling in Drosophila, linking it to feeding reduction and sleep promotion. The research identifies PLP neurons and enteroendocrine cells as key mediators and demonstrates modulation by the circadian neuropeptide PDF. The dataset includes associated tags such as Brain Gut Peptide, Midgut, and Galanin Signalling.

Use Cases

• Analyze the relationship between AstA-expressing PLP neuron activation and changes in feeding and sleep metrics.
• Investigate the functional PDF receptor expression in PLP neurons using cAMP imaging data referenced in the study.
• Examine the effects of silencing AstA signalling or providing continuous PDF input on the sleep/activity ratio.
• Study the conserved galanin receptor homologs in AstA signaling pathways as mentioned in the research description.

Strengths

• Data originates from a peer-reviewed scientific study published in 2020.
• The dataset is explicitly tagged with specific biological concepts like 'Brain Gut Peptide' and 'Circadian Control'.
• It is licensed under CC0-1.0, allowing for unrestricted reuse.

Limitations

• The specific data format, column structure, and row count are unknown, limiting immediate analytical utility.
• The dataset scope is confined to a specific experimental model (Drosophila), which may limit generalizability to other organisms.
• As a static research output from 2020, the data may not reflect the most recent findings in the field.

Provenance

Source

Dryad digital repository.

Collection Method

Experimental data generated from thermogenetic activation, cAMP imaging, and behavioral assays in Drosophila.

Time Range

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Freshness

Last updated on 2020-06-24.

Geography

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