Resting-State fMRI Connectivity In Ultra-High-Risk Psychosis Individuals

Featuring resting-state functional magnetic resonance imaging data from 110 participants, including 22 first-episode psychosis patients, 41 individuals at ultra-high-risk for psychosis, and 47 healthy controls. It was collected to investigate subregion-specific functional connectivity of the superior temporal gyrus.

Use Cases

• Analyze seed-based connectivity differences from the left planum temporale seed between FEP, UHR, and control groups.
• Correlate connectivity strength between the left planum temporale and right dorsolateral prefrontal cortex with positive symptom severity scores in UHR individuals.
• Compare functional connectivity from bilateral Heschl's gyrus seeds to the dorsal anterior cingulate cortex across participant groups.
• Examine fronto-temporal connectivity patterns specific to the planum polare, Heschl's gyrus, and planum temporale subregions.

Strengths

• Includes data from 110 participants across three clinically distinct groups for comparative analysis.
• Focuses on three anatomically defined subregions (planum temporale, Heschl's gyrus, planum polare) of the superior temporal gyrus in each hemisphere.
• Contains clinical correlation data, such as the positive symptom severity metric for UHR individuals.

Limitations

• Sample size is modest with 110 total participants, limiting statistical power for subgroup analyses.
• Dataset is cross-sectional, providing no longitudinal data on conversion from UHR to psychosis.
• Specific imaging parameters, preprocessing pipelines, and exact connectivity matrices are not described in the provided input.

Provenance

Source

Author: Youngwoo Bryan Yoon. Platform: Dryad.

Collection Method

Resting-state functional magnetic resonance imaging collected from clinical and control participants.

Freshness

Data was last updated in June 2020.