Rat Intestinal Electrical Impedance Data for IBD Model

Experimental data from a study correlating electrical transmural impedance with histological inflammation in a rat model of inflammatory bowel disease. The research used four platinum ball electrodes placed in the rat small intestine to measure impedance changes over a 3-hour testing period following TNBS injection. The dataset supports the development of a real-time, quantitative diagnostic method for mucosal barrier function.

Use Cases

• Correlate electrical impedance measurements with histologically assessed mucosal damage scores.
• Analyze impedance changes relative to increases in neutrophil, eosinophil, and T-cell population counts from tissue samples.
• Model the relationship between intraluminal TNBS injection and subsequent decreases in transmural impedance.

Strengths

• Data is derived from a controlled in vivo experimental model using an established TNBS-induced IBD protocol.
• Impedance measurements were recorded in real-time over a defined 3-hour testing period.
• Findings include statistically significant correlations (P < 0.05) between impedance changes and histological measures.

Limitations

• The dataset is limited to a single animal model (rat) and may not generalize directly to human IBD pathophysiology.
• Sample size and the number of experimental subjects are not specified in the provided description.
• Data granularity and specific measurement variables (e.g., raw impedance values, time-series frequency) are unknown.

Provenance

Source

Dryad digital repository.

Collection Method

In vivo experimental measurements from rat small intestine using platinum ball electrodes, correlated with post-experiment histological analysis.

Time Range

Experimental testing period of 3 hours.

Freshness

Last updated in June 2020.