Retinal Response to Bevacizumab in Branch Retinal Vein Occlusion Patients

27 treatment-naive eyes with macular edema secondary to branch retinal vein occlusion were studied prospectively. The dataset contains pre- and post-injection measurements of central foveal thickness, best corrected visual acuity, and multifocal electroretinogram amplitudes in affected and fellow eyes. It was collected by Pukhraj Rishi and published in 2020 to analyze potential ischemic effects of a single intravitreal bevacizumab injection.

Use Cases

• Analyze the change in central foveal thickness (CFT) before and after bevacizumab injection to assess treatment efficacy for macular edema.
• Correlate best corrected visual acuity (BCVA) logMAR values with CFT measurements to model visual outcome predictors.
• Compare N1 and P1 mfERG amplitudes in the 'unaffected quadrant' of treated eyes to corresponding quadrants in fellow eyes to study systemic drug absorption effects.
• Calculate inter-observer agreement kappa values for measured parameters to assess data reliability in a clinical study setting.

Strengths

• Includes paired pre- and post-treatment data for 27 patients, enabling within-subject analysis.
• Reports specific statistical results including P-values and 95% confidence intervals for key outcomes like CFT and BCVA.
• Contains multi-modal clinical measurements: fluorescein angiography, optical coherence tomography, and multifocal electroretinogram data.

Limitations

• Small sample size of 27 eyes, as noted by the authors, limiting statistical power.
• Short follow-up period after a single drug injection, preventing assessment of long-term or cumulative dose effects.
• Study conducted at a single tertiary care center, which may limit generalizability and contributed to the limited sample size.

Provenance

Source

Dryad digital repository.

Collection Method

Prospective, interventional case-series with standardized ophthalmological examinations.

Time Range

Study period not specified; dataset was published in 2020.

Freshness

Data reflects a study published in 2020.

Geography

Location of the tertiary care center not specified.