Parkinson's Disease Mortality Predictors After Deep Brain Stimulation

143 consecutive Parkinson's disease patients were assessed for motor and cognitive symptoms before and up to 10 years after subthalamic nucleus deep brain stimulation (STN-DBS) surgery. The dataset tracks symptom progression, treatment efficacy attenuation, and mortality, with a median observation time of 12 years after surgery. Axial disability level was the only symptom significantly predicting death, with a hazard ratio of 4.30 per unit increase.

Use Cases

• Model mortality risk using the current level of axial disability as a predictor, based on the reported hazard ratio of 4.30.
• Analyze the progression of akinesia, rigidity, and axial symptom scores over a 10-year period following STN-DBS surgery.
• Investigate the attenuation of treatment efficacy for dopaminergic medication and STN-DBS on specific motor symptoms over time.
• Assess the relationship between cognitive status decline and long-term patient outcomes within the 12-year median follow-up.

Strengths

• Long-term follow-up with a median observation time of 12 years after surgery.
• Detailed longitudinal tracking of motor symptoms (akinesia, rigidity, axial) at multiple time points: before, and 1, 2, 5, and 10 years after STN-DBS.
• Includes mortality data with causes of death recorded for 41 deceased patients.

Limitations

• Sample size is limited to 143 patients from a single center, which may limit generalizability.
• Specific column names and raw data structure are not provided in the input.
• Data collection ended with the last update in 2020, so it does not reflect the most recent treatments or patient outcomes.

Provenance

Source

Dryad digital repository, authored by Brian Lau.

Collection Method

Clinical assessments of 143 consecutive PD patients before and after STN-DBS surgery, using linear mixed-models and joint models for analysis.

Time Range

Long-term follow-up with assessments spanning up to 10 years post-surgery and a median observation of 12 years.

Freshness

Last updated on 2020-06-24.

Geography

Data is associated with Paris, as indicated in the tags.