Cavin-3 Knockout and Overexpression Signaling Data

A 2020 study by Peter Michaely investigates the tumor suppressor protein Cavin-3 and its role in cellular signaling. The dataset contains experimental results from in vivo knockout and in vitro gain/loss-of-function approaches, examining the balance between ERK and Akt signaling pathways. It explores downstream consequences including metabolic shifts, cell proliferation, and apoptosis resistance.

Use Cases

• Analyze the relationship between Cavin-3 expression levels and measured changes in ERK versus Akt signaling activity.
• Model the impact of Cavin-3 loss on downstream metabolic markers like aerobic glycolysis and lactate production.
• Investigate correlations between caveolae number, as influenced by Cavin-3, and activation of the ERK signaling module.
• Study the regulatory link between Cavin-3, EGR1, and PTEN expression in the context of Akt pathway promotion.

Strengths

• Data originates from a peer-reviewed biological study with a clear mechanistic hypothesis.
• Experimental design includes both in vivo and in vitro validation across multiple model systems (Homo Sapiens, Mus musculus).
• Released under a permissive CC0 1.0 public domain license, enabling broad reuse.

Limitations

• Specific data structure (rows, columns, file formats) is not described, complicating direct technical assessment.
• Sample data is unavailable, preventing verification of data format and completeness prior to download.
• The dataset's last update was in 2020, potentially limiting relevance to the most recent research findings.

Provenance

Source

Dryad digital repository.

Collection Method

Generated from in vivo knockout and in vitro gain/loss-of-function experiments.

Freshness

Last updated 2020-06-30.