NHP Cardiac MRI: Repeatability of Left Ventricular Function Biomarkers

Magnetic resonance imaging (MRI) biomarkers characterizing regional left ventricular function in cynomolgus nonhuman primates, published by Smita Sampath in 2020. It utilizes MR tagging and phase contrast imaging to quantify cardiac strain, flow, and rotational mechanics across multiple subjects. The data includes specific measurements for test-retest repeatability and inter-subject variability to validate biomarkers for pre-clinical drug studies.

Use Cases

• Validating the reliability of peak strain and systolic strain-rate as biomarkers for pre-clinical heart failure drug trials
• Analyzing the E/CSR and E/LSR ratios to assess diastolic filling efficiency in primate models
• Modeling the temporal inter-relationships between rotational mechanics and LV chamber flow

Strengths

• Utilizes dual imaging modalities: MR tagging and phase contrast (PC) imaging
• Provides test-retest repeatability metrics for longitudinal study validation
• Includes complex rotational mechanics such as peak torsion and untwist rates

Limitations

• High inter-subject variability reported for strain dyssynchrony and diastolic strain-rates
• Small sample size inherent to nonhuman primate research
• Species-specific data may not fully generalize to all large animal models

Provenance

Source

Dryad Digital Repository

Collection Method

Experimental data collection using MR tagging and phase contrast imaging on cynomolgus monkeys

Freshness

Last updated June 2020; represents a static study of repeatability.