Mouse Brain-Wide Fear Memory Network Chemogenetic Interrogation Data

A dataset from a study chemogenetically silencing 21 brain regions to test network hub importance for fear memory consolidation. The data supports the hypothesis that highly connected hub regions, identified via c-fos expression mapping and in silico network analysis, produce the largest memory deficits when silenced. It includes results from independent experiments covering 25% of an 84-region functional network.

Use Cases

• Analyze the relationship between node degree from a functional connectivity network and observed memory consolidation deficits after chemogenetic silencing.
• Validate in silico network disruption predictions (e.g., reduction in global efficiency) against in vivo experimental outcomes from 21 brain regions.
• Investigate the behavioral impact of silencing specific brain regions like the Reuniens Thalamic Nucleus or Lateral Septal Nucleus on contextual fear conditioning.

Strengths

• Data is derived from a systematic experimental series encompassing 21 brain regions, representing 25% of a defined 84-region network.
• Findings are grounded in a multi-method approach combining c-fos mapping, in silico network simulation, and in vivo chemogenetic validation.
• Dataset is openly licensed under CC0-1.0, facilitating unrestricted reuse and analysis.

Limitations

• The dataset scope is limited to 21 out of 84 identified network nodes, leaving the majority of the theoretical network untested experimentally.
• Data is specific to a mouse model of contextual fear conditioning, limiting direct generalizability to other behaviors or species.
• The raw data format, column structure, and sample size are not described, complicating immediate analytical use.

Provenance

Source

Dryad digital repository.

Collection Method

Generated from chemogenetic silencing experiments in mice, following brain-wide c-fos expression mapping and in silico network analysis.

Freshness

Last updated in June 2020.