Longitudinal MRI and Behavioral Data in Huntington's Disease Mouse Model

Longitudinal MRI volume measurements and behavioral assessments from a study of HdhQ150 knock-in mice modeling Huntington's disease. It includes data on motor impairments, cognitive function, and regional brain atrophy tracked over 94 weeks. The study was conducted by Ivan Rattray and published in 2020.

Use Cases

• Analyze correlations between MRI-derived striatal volume changes and motor impairment scores like rotarod performance.
• Model the temporal progression of regional brain atrophy (e.g., cortex, hippocampus) using longitudinal T2-weighted MRI measurements.
• Investigate potential relationships between histologically observed mHTT aggregates and behavioral outcome measures such as grip strength or fear conditioning.
• Apply tensor-based morphometry to contrast patterns of brain growth and neurodegeneration across different brain regions over time.

Strengths

• Longitudinal data collection spanning 94 weeks, capturing pre-manifest and manifest disease stages.
• Multi-modal data integration, combining behavioral tests, MRI volumetry, and histopathology.
• Quantified specific atrophy percentages, including a 27% striatal decrease over the study period.

Limitations

• Sample size is not specified, limiting assessment of statistical power.
• The description notes a lack of strong correlations between molecular pathology and behavioral outcomes, which may constrain predictive modeling.
• Data is specific to the HdhQ150 mouse model, and generalizability to other models or human disease may be limited.

Provenance

Source

Dryad digital repository.

Collection Method

Experimental data from longitudinal study of HdhQ150 knock-in mice, including behavioral testing, MRI scans, and histology.

Time Range

Study conducted over 94 weeks.

Freshness

2020-06-24