Human Amygdala and Hippocampus Single Neuron Activity During Memory Tasks

1,576 single neurons were recorded from the human amygdala and hippocampus across 65 sessions involving 42 patients. The dataset includes spike times, extracellular waveforms, behavioral responses, electrode locations, demographics, and visual stimuli from a recognition memory task. Subjects identified images as 'new' or 'old' using a 1-6 confidence scale.

Use Cases

• Analyze spike times and waveforms to investigate neural correlates of memory encoding and recognition.
• Model the relationship between behavioral confidence ratings (1-6 scale) and single neuron activity patterns.
• Map electrode locations from post-operative MRI scans to study regional specificity in the amygdala and hippocampus.
• Examine demographics and session data to control for patient-specific factors in neural signal analysis.
• Use provided spike sorting quality metrics to validate the presence of visually- and memory-selective cells.

Strengths

• Contains 1,576 single neuron recordings, a substantial number for human intracranial studies.
• Data originates from 65 sessions across 42 patients, providing multiple observations per subject.
• Includes technical validation metrics like spike sorting quality and cell tuning assessments.
• Comes with analysis code to reproduce key scientific findings from prior research.

Limitations

• Data is from a specific patient population undergoing epilepsy monitoring, which may limit generalizability to healthy brains.
• The sample of 42 patients, while significant for this method, is relatively small for broad population inferences.
• The temporal coverage and update recency are not specified beyond the 2020 publication date.

Provenance

Source

Mailys C. M. Faraut et al., published via Dryad.

Collection Method

Recorded during intracranial monitoring for epileptic seizure localization while patients performed a picture recognition memory task.

Freshness

Last updated 2020-06-24.