Genetic and Phenotypic Data of High-Altitude Tibetan Women in Nepal

A collection of genomic and phenotypic data from approximately 1000 ethnically Tibetan women from Nepal adapted to high altitude. It was used to study natural selection by combining genome-wide association analysis and tests for polygenic adaptations. The analysis provided evidence of selection for alleles associated with fertility traits like pregnancies and live births.

Use Cases

• Perform genome-wide association studies to identify genetic variants linked to fertility phenotypes like number of pregnancies and live births.
• Test for polygenic adaptations using genetic data to detect signals of positive or negative selection on specific physiological traits.
• Analyze the association between EPAS1 haplotypes and hemoglobin levels to investigate high-altitude adaptation mechanisms.
• Map the genetic bases of physiological phenotypes, such as offspring mortality, to understand evolutionary pressures.

Strengths

• Includes data from approximately 1000 individuals, providing a substantial sample for genetic association studies.
• Combines multiple analytical approaches: selective sweep detection, polygenic adaptation tests, and phenotype mapping.
• Focuses on a unique population of ethnically Tibetan women adapted to the high-altitude environment of Nepal.

Limitations

• The dataset is specific to a single ethnic group and geographic region, limiting generalizability to other populations.
• Sample data and specific column details are unavailable, which may hinder immediate analysis without further metadata.
• The data's last update was in 2020, potentially making it less current for recent genetic research trends.

Provenance

Source

Dryad digital repository.

Collection Method

Data gathered from genome-wide association analysis and polygenic adaptation tests on indigenous Tibetan women.

Freshness

Last updated on 2020-06-24.

Geography

High-altitude regions of Nepal.