Developmental Expression of Hepatic Drug Metabolizing Enzymes

A review of developmental trajectories for hepatic drug metabolizing enzymes, categorizing them into three classes based on perinatal changes. The data highlights significant interindividual variation in the timing of these changes, creating windows of hypervariability. It was authored by D. Gail McCarver and last updated in June 2020.

Use Cases

• Integrate developmental trajectories of Cytochrome P450 enzymes into physiologically-based pharmacokinetic models for pediatric dosing predictions.
• Analyze interindividual variation in the timing of perinatal changes for Sulfotransferase and UDP Glucuronosyltransferase enzymes to identify windows of hypervariability.
• Compare the relative impact of developmental factors versus genetic variation on Flavin Monooxygenase and Glutathione S-Transferase expression in children.
• Categorize Xenobiotic Metabolizing Enzymes into Class 1, 2, or 3 based on their reviewed developmental ontogeny patterns.

Strengths

• Focuses on a critical pediatric pharmacology challenge: the interplay between developmental ontogeny and pharmacogenetics.
• Covers nine specific enzyme families including Cytochrome P450, Sulfotransferase, and UDP Glucuronosyltransferase.
• Authored by a domain expert and published under a permissive CC0 1.0 license for unrestricted reuse.

Limitations

• The dataset is a review article, not primary experimental data, limiting direct analysis of raw measurements.
• No sample data, column definitions, or row counts are provided, restricting immediate computational use.
• The temporal coverage and specific sample demographics are not detailed, limiting generalizability.

Provenance

Source

Dryad digital repository.

Collection Method

A scholarly review synthesizing current knowledge on enzyme ontogeny.

Freshness

Last updated in June 2020.