Cough Frequency Dynamics in Pulmonary Tuberculosis Treatment

A clinical study recorded 670 cough episodes from 64 HIV-negative adults undergoing treatment for drug-susceptible pulmonary tuberculosis. The dataset includes repeated measurements from before treatment until day 62, with associated sputum bacillary load estimates from 252 culture-positive samples. It captures the circadian cycle of cough and its response to therapy.

Use Cases

• Model the relationship between sputum bacillary load and cough episodes/hour to predict transmission risk.
• Analyze the circadian cycle of cough frequency using time-stamped recordings to identify peak transmission periods.
• Track the reduction in median cough episodes/hour over the 62-day treatment period to assess therapeutic efficacy.
• Estimate the probability of culture conversion at 14 treatment days using the provided bacillary load data.

Strengths

• Contains 670 recorded cough episodes from a controlled clinical study.
• Longitudinal design with repeated measurements from 64 participants over a 62-day treatment period.
• Includes 252 culture-positive sputum samples with time-to-culture-positivity data for estimating bacillary load.

Limitations

• Small sample size of 64 participants limits generalizability of findings.
• Geographic bias as the study was conducted in Peru, which may not represent global TB populations.
• Data is from a single study completed in 2019 and may not reflect current treatment protocols.

Provenance

Source

Dryad, authored by Alvaro Proaño.

Collection Method

Prospective clinical evaluation using the Cayetano Cough Monitor and microscopic-observation drug-susceptibility broth culture.

Time Range

Measurements taken from immediately pre-treatment until treatment day 62.

Freshness

Last updated in June 2019.

Geography

Peru.