fMRI and Neuropsychological Data on Thyroid Hormone Effects

Functional MRI and neuropsychological test data from 29 healthy male subjects before and after an eight-week period of induced mild thyrotoxicosis. It was collected to evaluate the effects of thyroid hormone levels on working memory performance and brain activation patterns. The data includes results from an n-back working memory task and assessments like the Attention Network Task and auditory verbal learning test.

Use Cases

• Analyze fMRI activation differences in the prefrontal cortex and parahippocampal area between euthyroid and hyperthyroid states.
• Correlate reaction time and accuracy metrics from the n-back task with thyroid hormone levels.
• Model changes in auditory verbal learning test parameters as a function of induced thyrotoxicosis.
• Compare task-induced brain activation patterns in regions like the anterior cingulate cortex and insula across different n-back difficulty levels.

Strengths

• Data is from a controlled study with 29 human subjects.
• Includes longitudinal measurements before and after an eight-week intervention.
• Combines multiple data modalities: functional MRI, reaction times, accuracy scores, and neuropsychological test results.

Limitations

• Sample size is limited to 29 subjects, all of whom are male, limiting generalizability.
• The dataset's temporal coverage is specific to the eight-week study period.
• The raw data structure, column definitions, and file formats are not specified in the input.

Provenance

Source

Anna Göbel via Dryad.

Collection Method

Data collected from a controlled clinical study involving fMRI during an n-back task and neuropsychological testing before and after thyroid hormone intake.

Time Range

Covers the period before and after an eight-week intervention.

Freshness

Last updated in June 2020.