Mouse Cerebellar Neuron Activity During Active Locomotion

A collection of recordings from over 300 cerebellar neurons in awake mice performing an active locomotion task. It characterizes cell activity in relation to stepping cycle phase, locomotion speed, and yaw movements. The data was collected using high-density silicon electrode arrays to investigate sensorimotor integration in the cerebellar vermis.

Use Cases

• Decode locomotion speed using a linear algorithm based on the activity of well-chosen neurons.
• Analyze the proportion of cells tuned to locomotion speed (45%) versus those tuned to yaw movements (19%).
• Investigate how behavioral state modulates cerebellar sensorimotor integration by examining neuron activity during active locomotion.
• Compare phase modulation of neuron activity (53% of cells) between active and passive locomotion paradigms.

Strengths

• Contains recordings from over 300 cerebellar neurons, including Purkinje cells, Golgi cells, and mossy fibers.
• Data reveals specific tuning proportions: 53% of cells modulated by stepping phase, 45% tuned to speed, and 19% tuned to yaw.
• Recordings were made in awake mice engaged in an active locomotion task, providing ethologically relevant neural data.

Limitations

• The sample size of over 300 neurons may be limited for certain high-dimensional analyses or rare cell type investigations.
• Data is specific to the cerebellar vermis of mice (Mus musculus), limiting generalizability to other brain regions or species.
• The absence of detailed column or sample data descriptions may hinder immediate understanding of the data structure.

Provenance

Source

Tomaso Muzzu via Dryad.

Collection Method

Recorded using high-density silicon electrode arrays from mice engaged in an active locomotion task.

Freshness

Last updated in June 2020.

Geography

Associated with London; data from laboratory mice (Mus musculus).