Allele-Specific Substitutions in Young Fungal Mating-Type Chromosomes

207 genes from the Neurospora tetrasperma mating-type chromosomes were examined for protein-level genomic alterations within a young region of suppressed recombination. The dataset provides evidence of time-dependent, allele-specific non-synonymous codon substitutions associated with relaxed purifying selection. It serves as a model system for studying early genomic events in sex chromosome evolution.

Use Cases

• Analyze the ratio of non-synonymous (dN) to synonymous (dS) substitutions (ω) across 207 genes to detect signatures of relaxed purifying selection.
• Compare allele-specific non-synonymous codon substitutions between mat a and mat A chromosomes to identify independent evolutionary trajectories.
• Model the accumulation of non-synonymous substitutions in a time-dependent manner within the >6.6 Mb recombinationally suppressed region.
• Examine gene-specific patterns of genomic alteration to understand early stages of genomic degeneration in young sex chromosomes.

Strengths

• Focuses on a young (<6 million years old) region of recombination suppression, providing a rare snapshot of early sex chromosome evolution.
• Examines a specific set of 207 genes located on the mating-type chromosomes for targeted protein-level analysis.
• Data supports findings with maximum likelihood analyses of dN/dS ratios, linking substitutions to evolutionary processes.

Limitations

• The dataset is restricted to a single fungal species (Neurospora tetrasperma), limiting broad taxonomic inferences.
• Sample data and file formats are unavailable, hindering immediate reproducibility and analysis.
• The study's scope is specific to protein-coding changes, excluding potential structural or regulatory alterations.

Provenance

Source

Author C A Whittle via the Dryad repository.

Collection Method

Examination of alleles from 207 genes on mating-type chromosomes using maximum likelihood analyses of substitution rates.

Time Range

Evolutionary timescale of the young region (<6 million years).

Freshness

Last updated in June 2020.