Arabidopsis Mutant Sensitivity to Sulfamethoxazole from Genetic Screens

Encompassing results from two forward genetic screens in Arabidopsis thaliana to identify mutants with altered sensitivity to the phytotoxic compound sulfamethoxazole. The screens identified a mutant with reduced sensitivity linked to a 5-oxoprolinase gene and a mutant with enhanced sensitivity linked to a gene of unknown function. Row and column counts are not specified.

Use Cases

• Identify Arabidopsis genes influencing sensitivity to sulfamethoxazole based on seedling growth phenotypes from the screens.
• Analyze the role of the 5-oxoprolinase gene in plant responses to sulfanilamide compounds.
• Investigate the function of the unannotated gene associated with enhanced sensitivity to sulfamethoxazole.
• Study plant responses to sulfanilamides beyond the known inhibition of folate biosynthesis.

Strengths

• Data originates from controlled forward genetic screens in the model organism Arabidopsis thaliana.
• Identifies specific genes, including 5-oxoprolinase and an unannotated gene, as mediators of compound sensitivity.
• Published findings are associated with a peer-reviewed research study.

Limitations

• The dataset scope and structure, including row and column counts, are not described.
• Sample data and file formats are unavailable, limiting immediate usability assessment.
• The data is specific to Arabidopsis and sulfamethoxazole, limiting generalizability to other systems or compounds.

Provenance

Source

Dryad digital repository.

Collection Method

Forward genetic screens based on seedling growth phenotypes in the presence of sulfamethoxazole.

Freshness

Last updated in June 2020.