Bacteriophage λ J Protein Mutations and Natural Variants Analysis

Bacteriophage λ J protein sequence data and mutation analysis comparing laboratory gain-of-function experiments with natural variants. Created by Rohan Maddamsetti and published in 2020, the data identifies specific amino acid residues linked to host-receptor exploitation. It provides evidence for host-shift evolution in lambdoid viruses through phylogenetic analysis of insertions and deletions.

Use Cases

• Analyzing J protein amino acid diversity to predict host-receptor exploitation
• Comparing laboratory-evolved mutations against natural λ variants to validate gain-of-function models
• Identifying phylogenetic patterns of insertions and deletions to study ecological diversification in lambdoid viruses

Strengths

• Identifies two specific residues of the J protein required for host-receptor exploitation
• Pairs laboratory-evolved mutation data with natural λ variant sequences
• Released under a CC0-1.0 public domain license

Limitations

• Highly specialized focus on bacteriophage λ J protein residues
• Lack of explicit column headers or row counts in the provided metadata

Provenance

Source

Dryad, Rohan Maddamsetti

Collection Method

Laboratory evolution experiments and protein sequence analysis of natural variants

Freshness

Last updated June 2020; static research dataset.