Genetic Mapping of MAPK-Mediated Traits in S. Cerevisiae

Presenting quantitative trait locus (QTL) mapping results from a Round-robin cross between twelve diverse S. cerevisiae strains. It identifies genetic variants underlying phenotypic differences related to MAPK signaling cascades and interconnected pathways. The data was generated by Sebastian Treusch and published in 2020.

Use Cases

• Identify QTL influencing phenotypes dependent on MAPK signaling cascades across diverse yeast strains.
• Analyze genetic variants within MAPK signaling networks to understand pathway regulation.
• Leverage mapping results from multiple strain backgrounds to narrow the search for causal genetic variants.
• Study the impact of natural genetic variation on cellular signaling strategies conserved from fungi to humans.

Strengths

• Data is derived from a systematic cross of twelve diverse S. cerevisiae strains, providing genetic breadth.
• Focuses on MAPK signaling pathways, which are conserved and biologically significant.
• Published under a permissive CC0 1.0 license for unrestricted reuse.

Limitations

• The dataset's specific size, format, and granularity (e.g., row/column counts) are not provided.
• Data is from 2020 and may not reflect the most recent research findings.
• Analysis is specific to S. cerevisiae, limiting direct applicability to other organisms without comparative work.

Provenance

Source

dryad

Collection Method

Quantitative trait locus (QTL) mapping using a Round-robin cross between twelve diverse S. cerevisiae strains.

Freshness

Last updated 2020-06-24.