Human and Mouse Neocortex Synaptic Plasticity Electrophysiology Data

Data from a study by Guilherman Testa-Silva compares synaptic transmission properties between adult human and mouse temporal cortex neurons. The dataset contains electrophysiological recordings from connected pairs of pyramidal neurons, probing use-dependent plasticity and information transfer. It was published in 2020.

Use Cases

• Compare synaptic recovery times from depression between human and mouse neuron pairs.
• Calculate information transfer rates between pyramidal neurons using the study's theoretical framework.
• Analyze action potential phase-locking to input transients up to 1,000 cycles/s in human neurons.
• Model frequency tracking bandwidth differences between human and rodent principal cells.

Strengths

• Data directly compares adult human and mouse cortical physiology, a key experimental contrast.
• Findings quantify human synaptic recovery as three to four times faster than in rodents.
• Study calculates human information transfer exceeds mouse by four to nine times, into beta/gamma frequencies.

Limitations

• Dataset size, row count, and specific file structure are unknown from the provided input.
• Data is from acute brain slices, which may not fully capture in vivo network dynamics.
• The temporal and geographic coverage of the source tissue samples is not specified.

Provenance

Source

Guilherme Testa-Silva via Dryad.

Collection Method

Electrophysiological recordings from connected pairs of pyramidal neurons in acute brain slices of adult human and mouse temporal cortex.

Freshness

Last updated 2020-06-24.