Human Blood and Mucosal Treg Immunophenotyping in Inflammatory Bowel Disease

2020 research data characterizes FOXP3+ regulatory T cells (Tregs) and FOXP3- CD4+ T cells from intestinal lamina propria and blood samples of patients with and without inflammatory bowel disease (IBD). The dataset includes immunophenotyping results for markers such as Helios, CD39, CTLA4, and PD-1, comparing expression levels between cell populations and patient groups. It was authored by James D. Lord and published under a CC0 license.

Use Cases

• Compare Helios+ and Helios- FOXP3+ T cell frequencies between IBD patients and healthy controls to investigate Treg origins.
• Analyze expression levels of inhibitory receptors CD39, CTLA4, and PD-1 on FOXP3- cells in inflamed versus non-inflamed mucosal tissue.
• Correlate activation marker expression on Tregs relative to FOXP3- cells across different sample sources (blood vs. lamina propria).
• Investigate the phenotypic similarity of mucosal Tregs in IBD patients and controls using maturation and activation marker data.

Strengths

• Data includes comparative immunophenotyping from two distinct biological compartments: intestinal lamina propria and blood.
• Analysis covers multiple specific cell markers (Helios, CD39, CTLA4, PD-1) and cell types (FOXP3+ Tregs, FOXP3- CD4+ T cells).
• Dataset is associated with a peer-reviewed research study, providing methodological context.
• Published under a permissive CC0 license, facilitating reuse.

Limitations

• Sample size and number of individual donors are not specified, limiting assessment of statistical power.
• Raw data format, column structure, and row count are unknown, complicating direct analysis.
• Data is from a single 2020 study; findings may not reflect latest research or broader patient demographics.

Provenance

Source

Dryad digital repository.

Collection Method

Immunophenotyping of cells from surgically resected intestinal lamina propria and blood samples from patients with and without IBD.

Freshness

Last updated 2020-06-24.