IL-33 and Immune Response Data from Human Trauma Cohort and Mouse Model

Featuring data from a study of 472 severely injured human blunt trauma patients and a mouse model of hemorrhagic shock and tissue trauma. It examines dynamic changes in plasma IL33, sST2, and type 2 cytokine levels (IL4, IL5, IL13) and their correlation with nosocomial infection and organ dysfunction. The study uses a reverse translation approach from human observations to mechanistic experiments in mice.

Use Cases

• Correlate plasma IL33 levels with IL4, IL5, and IL13 levels in 472 trauma patients to analyze early type 2 immune responses.
• Compare IL33 and sST2 level trajectories between patients who developed nosocomial infection and those who did not.
• Model the IL33–ILC2–IL5–neutrophil axis using data from mouse models of HS/T to investigate acute lung injury mechanisms.
• Analyze the delayed increase in sST2 levels relative to IL33 elevations after severe injury in both human and mouse data.

Strengths

• Includes data from a substantial human cohort of 472 severely injured blunt trauma patients.
• Employs a reverse translation study design, linking observational human data with mechanistic mouse model experiments.
• Focuses on specific, measured biomarkers: IL33, sST2, IL4, IL5, and IL13.

Limitations

• The human study component is descriptive in nature, limiting causal inference.
• Potential differences between human and mouse immune responses may affect the translatability of mechanistic findings.
• The study does not permit conclusions about the impact of IL33 on pulmonary function.

Provenance

Source

Dryad digital repository.

Collection Method

Observational study of trauma patients with frequent blood sampling, combined with controlled experiments in mouse models including wild-type and genetically modified strains.

Freshness

Data last updated in June 2020.

Geography

Patients admitted to a level I trauma center; specific location not stated.