Pancreatobiliary Adenocarcinomas: 409 Samples with 27 IHC Markers

409 tumor samples from patients with pancreatobiliary adenocarcinomas were analyzed using up to 27 immunohistochemical antibodies to improve diagnostic accuracy. Created by Carlos Fernandez Moro and updated in 2020, the data includes immunohistochemical scoring based on the percentage of stained tumor cells.

Use Cases

• Classification of tumor types using immunohistochemical scoring of 27 antibodies
• Survival analysis using hazard ratios for intestinal vs. pancreatobiliary types
• Identification of discriminant markers for intrahepatic cholangiocarcinoma diagnosis

Strengths

• 409 tumor samples
• 27 conventional antibody markers
• Expert-annotated immunohistochemical scoring
• Includes survival analysis data

Limitations

• Single-center study from one tertiary referral center
• Retrospective observational cohort design
• Potential for overlapping morphological features in periampullary cancers

Provenance

Source

Carlos Fernandez Moro, tertiary referral center

Collection Method

Retrospective observational cohort study of diagnostic core needle biopsies and surgical resections