Hippocampal Place Cell Recordings in Rett Syndrome Mouse Model

Featuring in vivo recordings from hippocampal place cells in freely moving Mecp2+/- mice, a model for Rett syndrome, and littermate controls. It was generated by Sara E. Kee to investigate how the disease state alters memory circuit functions, specifically spatial memory codes. The data captures neural activity related to spatial information encoding, baseline firing synchrony, and experience-dependent changes.

Use Cases

• Analyze the experience-dependent increase of spatial information in place cells to compare RTT mice and controls.
• Examine baseline firing synchrony of place cells within ripple oscillations during rest periods.
• Investigate the relationship between enhanced baseline synchrony and the occlusion of post-experience synchrony increase in RTT mice.
• Correlate neural activity patterns, such as place cell spatial information and synchrony, with contextual memory performance at short and long time scales.

Strengths

• Data originates from a controlled scientific study investigating a specific neurological disorder model.
• Includes comparative neural recordings from both disease model (RTT mice) and littermate control groups.
• Focuses on hippocampal place cells, which are a well-defined neural correlate of spatial memory.

Limitations

• The dataset size, including the number of recordings, subjects, or rows, is unspecified.
• Specific data columns, file formats, and structure are not described, limiting immediate usability.
• Data is from a specific animal model (mouse), and direct applicability to human Rett syndrome may be limited.

Provenance

Source

Sara E. Kee, via the Dryad repository.

Collection Method

In vivo electrophysiological recordings from hippocampal place cells in freely moving mice.

Freshness

Last updated on 2020-06-30.