Structural MRI Data for Schizophrenia and Bipolar Disorder Analysis

A collection of structural MRI data from a cohort of 823 individuals, including 226 with schizophrenia, 227 with bipolar disorder, and 370 healthy comparison subjects. It was used to model the confounding effects of head motion on cortical thickness and surface area measurements. The analysis raises questions about the regional specificity of structural brain changes in these illnesses.

Use Cases

• Model the influence of head motion on cortical thickness and surface area measurements across diagnostic groups.
• Compare cortical thickness reductions between schizophrenia and bipolar disorder cohorts to assess illness specificity.
• Analyze surface area changes, which were observed only in schizophrenia, to differentiate it from bipolar disorder.
• Investigate the relationship between global neuroanatomical indices and vertex-level analyses for group differences.

Strengths

• Dataset includes a substantial cohort of 823 individuals scanned with similar protocols.
• Provides data for three distinct groups: 226 schizophrenia, 227 bipolar disorder, and 370 healthy comparison subjects.
• Specifically models head motion as a confounder for structural MRI measurements.

Limitations

• The effect sizes for observed structural differences were reported as small to medium.
• Regional specificity of findings was questioned, as between-group effects became nonsignificant when global indices were covaried.
• Sample sizes, while substantial, may limit generalizability to broader populations.

Provenance

Source

Dryad

Collection Method

Structural MRI scans collected from individuals on a research-dedicated MRI with broadly similar protocols.

Freshness

Data was last updated in June 2020.