Metabolomic Profiles of Mycobacterium tuberculosis Under Antibiotic Stress

Metabolomic data from Mycobacterium tuberculosis exposed to isoniazid, rifampicin, and streptomycin antibiotics. The dataset supports research into the role of isocitrate lyases in antibiotic tolerance and antioxidant defense mechanisms. It was authored by Madhumitha Nandakumar and last updated in June 2020.

Use Cases

• Identify metabolic changes associated with isoniazid, rifampicin, and streptomycin exposure to understand drug response pathways.
• Analyze the activation of isocitrate lyases (ICLs) as a common marker across three different antibiotic treatments.
• Model the relationship between ICL activity and antibiotic susceptibility in Mycobacterium tuberculosis strains.
• Investigate the chemical rescue of antibiotic susceptibility using antioxidant co-incubation data.

Strengths

• Data generated from metabolomic profiling of a clinically significant pathogen, Mycobacterium tuberculosis.
• Includes results from three distinct, clinically used TB drugs: isoniazid, rifampicin, and streptomycin.
• Findings published in 2020, providing contemporary insights into antibiotic tolerance mechanisms.

Limitations

• The specific data structure, including row count, column names, and file formats, is not provided.
• Sample data is unavailable, limiting preliminary assessment of data granularity and completeness.
• The dataset's temporal scope and sample replication details are unspecified.

Provenance

Source

Dryad digital repository.

Collection Method

Metabolomic profiling of Mycobacterium tuberculosis cultures under antibiotic treatment.

Freshness

Last updated on 2020-06-24.